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Fourth, clinical translational potential is underdeveloped: there is a lack of clinical cohort data to confirm whether ferroptosis biomarkers (e.g., GPX4 downregulation and lipid peroxide accumulation) are elevated in kidney stone patients, and preclinical studies have not addressed whether targeting ferroptosis can reduce stone formation or recurrence (rather than just protecting tubular cells in vitro )

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Acknowledgements We thank Geok Kheng Tan and Irwan Iskandar Bin Roslan for solving X-ray crystal structure