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Implicated mechanisms include upregulation of molecular pathways involved in oxidative stress, aberrant calcium signaling, silencing of transcription factors and histone deacetylases, and deregulation of cytoskeleton-associated proteins

Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

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This allows the cells to bypass the BBB and enter the CNS directly

It aims to highlight current innovations in carnitine analysis and inspire future breakthroughs impacting nutrition, diagnostics, and therapy

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