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Its cardiac effects are indirect and GH-IGF-1-mediated: in post-MI C57BL/6J mice receiving CJC-1295 non-DAC at 10 g/kg 3/week for 4 weeks, LVEF improves from 38 3% to 44 4% an effect blocked by IGF-1R antibody (6872%), confirming IGF-1R-mediated cardiomyocyte survival as the mechanism

doi: 10.1002/advs.202310065 119 WangTGnanaprakasamJNRChenXKangSXuXSunHet al

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Buprenorphine plasma exposure (area under the plasma concentration-time curve over 28 days) was comparable across injection site groups with mean buprenorphine plasma concentrations sustained at approximately 2 ng/mL (therapeutic target concentration) or above

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(2) L T Phung, A Sasaki, H G Lee, R A Vega, (2001) Effects of the administration of growth hormone-releasing peptide-2 (GHRP-2) orally by gavage and in feed on growth hormone release in swine Domestic Animal Endocrinology, 2001 Jan, Volume 20 (Issue 1), Pages 9-19