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Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), sense microbial components and damage-associated molecular patterns (DAMPs), triggering activation of signaling cascades such as NF-B, MAPK, and inflammasomes (e.g., NLRP3), which further amplify the inflammatory response [40]

Thus, metabolic mechanisms during prolonged fasting reflect a well-balanced interplay between catabolic and anabolic reactions (Fig