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Disclosures: Prashanth Thevkar Nagesh: Nothing to Disclose, Yuan Zhuang: Nothing to Disclose, Mrigya Babuta: Nothing to Disclose, Marti Ortega-Ribera: Nothing to Disclose, the AlcHepNet clinical investigators: Nothing to Disclose, Gyongyi Szabo: CYTA Therapeutics: Consultant, Durect Corporation: Consultant, Merck: Consultant, Pandion Therapeutics: Consultant, Pfizer: Consultant, Terra Firma: Consultant, LabCorp: Consultant, Takeda: Consultant, Surrozen: Advisor, Intercept: Advisor, Evive: Advisor, Glympse Bio, Inc (acquired by Sunbird Bio): Advisor, Satellite Biosciences: Advisor, Zomagen Bioscience/Ventyx Biosciences: Consultant, Springer Nature Group: Royalties or patent beneficiary, UpToDate Inc: Royalties or patent beneficiary 1540 ELEVATED SYSTEMIC IGM ANTIBODIES TARGETING MALONDIALDEHYDE ADDUCTS PROMOTE ALCOHOL-ASSOCIATED LIVER DISEASE VIA COMPLEMENT ACTIVATION Dragana Raji 1 Beatriz Silva 1 Benedikt Simbrunner 2 Benedikt Hofer 1 Constanze Hoebinger 1 Nikolina Papac-Milicevic 1 Mattias Mandorfer 2 Thomas Reiberger 2 Tim Hendrikx 2 , 1 Medical University Vienna, 2 Medical University of Vienna Background: Alcohol- associated liver disease (ALD) associates with elevated immunoglobulin type M (IgM) levels in circulation

This localized phenomenon profoundly underscores the specific remodeling of the local endocrine microenvironment by inflammation: (104)

Schieber A, Berardini N, Carle R

USA 93 , 67436748 (1996)

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For induction of trained immunity ex vivo, mice were treated with 1 mg -glucan or PBS