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229 Due to the considerable genetic and clinical heterogeneity, mitochondrial diseases can affect either single or multiple organ systems, leading to a wide range of clinical manifestations (Fig

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Ion-exclusion chromatography with pulsed-amperometric detection (IC-PAD) IC-PAD analysis was performed on a Thermo Scientific (Reinach, Switzerland) ICS-5000+ system equipped with a quaternary gradient pump, a thermostated autosampler and an electrochemical detector with a cell containing a Ag/AgCl reference electrode and a disposable thin-film platinum working electrode tempered at 25 C

Similar content being viewed by others Introduction The reversible formation of disulfide bonds between cysteine residues is increasingly recognized as an important mechanism for the regulation of protein function