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Interestingly, the prevalence of hyperuricemia is higher in coastal areas and countries than in landlocked countries, especially for countries surrounded by sea and in developing

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"Further, while we acknowledge the corrective and preventive actions that your site has taken or plans to take, your written response is inadequate because it does not provide sufficient details about how you, as a clinical investigator, will ensure adequate oversight of the study procedures (for example, adherence to eligibility requirements)