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Common sources of exosomes include: MSC-derived exosomes PRP-exosome hybrids Adipose exosomes Platelet-derived extracellular vesicles (P-EVs) The following chart shows the efficacy of various exosomes for pain reduction and cartilage regeneration: BMAC and MFAT BMAC (Bone Marrow Aspirate Concentrate) and MFAT (Micro-Fragmented Adipose Tissue) are orthobiologics rich in mesenchymal stem cells (MSCs), growth factors, and anti-inflammatory mediators

Peptides were assessed using a NanoDrop spectrophotometer (Thermo Fisher Scientific, Waltham, MA)

Lysine Acetyltransferase 6A (KAT6A) decreased in old MSCs, coinciding with reduced proliferation, colony formation, and osteogenesis of MSCs by regulating antioxidant gene Nrf2 to inhibit ROS accumulation [111]

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Whereas -sitosterol demonstrated moderate to high positive correlations with most parameters, except for MDA and H 2 O 2 where negative correlations were observed (Supplementary Fig