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Immunomodulatory approaches (Checkpoint inhibitors, vaccines) Recent trials and preclinical studies demonstrate that modulating the immune system by targeting inflammation-related immunosuppressive pathways can enhance therapeutic efficacy in ovarian cancer [238]

The TCM views the inhospitable high-altitude environment, marked by low atmospheric pressure, oxygen scarcity, and coldness, as environmental factors that can cause diseases. When the human body is exposed to such an environment and its self-regulatory capacity proves insufficient (e.g., weak cardiopulmonary function or low metabolic efficiency), oxygen delivery is obstructed, and energy metabolism becomes abnormal

A review of the role of hypoxia in radioresistance in cancer therapy

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In animal models (rats), its effects on the nitric oxide (NO) pathway through modulation of NO synthase (eNOS) expression have been described

GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohns disease