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Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimers disease

However, 3 enzymes involved in the last steps of the de novo pathway, namely kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), and the rate limiting nicotinate-nucleotide pyrophosphorylase (QPRT) were upregulated in the kidneys of cKOt mice (Figure 4 and Supplemental Figure 3)

If a pair of allosteric effectors of metabolites and the responsible metabolic enzyme has more than one K i value among three species, we calculated the geometric mean of the K i values and used it as the K i value for that paired regulation