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Furthermore, a year-long study of individuals with mild Alzheimers disease (using an erinacine-enriched mycelial extract) reported cognitive benefits versus a placebo 13

However, adipose-ARKO resulted in increased mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1), uncoupling protein 2 (UCP2), and fatty acid mitochondrial transporter (CPT1) in epididymal WAT, suggesting that adipose-specific AR may be involved in lipid mobilization and fatty acid metabolism