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The findings stimulate further studies in large biobank samples to clarify whether such signatures could prove valuable for detecting pathology or follow-up of treatment effect in clinical trials

Expect gradual improvement rather than overnight transformation

compare iHLO protein profiles with native liver tissue and highlighted enrichment of detoxification pathways in both systems, emphasizing the relevance of organoids for metabolically intensive applications 15

FA may react with thiols present in the culture medium, limiting the amount of FA available to enter cells

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These cytokines mediate local inflammatory responses and contribute to renal tissue injury through direct cytotoxic effects and promotion of oxidative stress