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It was shown that lymphocytes of mice with the mutation in the gene coding CD95 receptor and cell lines resistant to CD95-L are resistant to a number of chemotherapeutic drugs [67-69]

J Sex Med 2013;10:230-44

Liver cirrhosis and cancer are relatively common in MASLD patients

Therefore, the authors concluded that this functionality and presence of a terminal electronegative group in general prevents tight binding of BIBF1202 in UGT1A1 active site, resulting in no UGT1A1 inhibition in in vitro experiments