Regulation of BACH1 Stabilization At high heme concentration, heme directly binds to BACH1 via six cysteineproline motifs located in an intrinsically disordered region, and heme binding induces a global conformational change in BACH1's hemebinding region, [ 20 22 ] thus inactivating BACH1 DNAbinding activity, [ 23 ] and facilitating BACH1's nuclear export and degradation
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doi: 10.1016/j.carres.2009.05.023 30
56 Paul Anthony Gliebe Jr
It upregulates GH production at the transcriptional level, meaning the pituitary's capacity to produce GH increases over weeks of sustained administration
