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Compared to other microtubule inhibitors, Noscapine selective nature allows for less toxicity and no peripheral neuropathy, hypothesized to arise from dysfunctional cell cycle checkpoint mechanisms in tumor cells that make them more vulnerable to mitotic slippage and cell death upon exposure (168, 169)

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While our study has shed light on a prospective protective function for astaxanthin against GUD, further mechanistic studies are needed to rule out the major downstream key players involved in this effect