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Body mass increased only 30% in old Has1,3 dko mice and was less than old WT mice

It is projected that over 33,000 people in Europe alone die annually from resistant bacterial-related infections, making it a near equal health burden to influenza, HIV, and tuberculosis combined (Cassini et al., 2018, 2019)

Scurvy, a severe vitamin C deficiency disease characterized by weakness, lethargy, easy bruising and bleeding, was particularly problematic for sailors on long voyages during the 16th century, where access to fresh fruits and vegetables was limited

189 -Ketoglutarate acts as an epigenetic regulator affecting demethylase activity, whereas citrate reshapes chromatin structure through ACLY-mediated histone acetylation

De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D.I., Cristofori, F., Guerzoni, M.E., Gobbetti, M

Instead of normal mitochondrial oxygen consumption (Sancho et al., 2016)