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Molecular mechanisms provide further in vitro evidence that supports the ANLS hypothesis (Bliss et al., 2004), showing that upregulation of glycolysis in neurons decreased oxidation of glucose through the pentose phosphate pathway, resulting in impaired regeneration of reduced glutathione, and subsequently oxidative stress and apoptotic death

In addition, induction of apoptosis has also been shown to reverse drug resistance

Zhao, Y., Zhang, J., Zheng, Y., Zhang, Y., Zhang, X., Wang, H., Du, Y., Guan, J., Wang, X., & Fu, J

Besides the anemia, a prolonged lack of B12 could lead to serious neurological damage, even paralysis

This is why research suggests that an optimal combination of the three vitamins, B1, B6 and B12, is more effective at relieving nerve damage symptoms and restoring nerve function than taking a single vitamin supplement

Oxidative stress occurs when you have an imbalance between free radicals and antioxidants in your body