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doi:10.1038/sj.embor.7400036

Oxidation of methionine and acetylation of the protein N-terminus were selected for variable modifications, whereas carbamidomethylation of cysteines were chosen for fixed modification

National institute of environmental health sciences

Emerging innovations such as bispecific ADCs, immune-stimulatory payloads, AI-guided design, and nanotechnology-enhanced delivery are reshaping the ADC landscape

Furthermore, in animal experiments, it was observed that elevated neutrophil infiltration into muscle, kidney, and liver may exacerbate tissue injury (149, 150), and neutrophil depletion can be a factor alleviating liver damage following exhaustive exercise (150)