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Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)

Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes

Notably, nutrient deprivation-induced ERS also influences the tumor immune microenvironment, transmitting regulatory signals via exosomes and other carriers to suppress T-cell function and promote the polarization of immunosuppressive M2-type macrophages [24]

Apart from its role in the immune system, NADPH is required by the enzyme glutathione reductase to regenerate reduced glutathione, a key endogenous antioxidant that protects cells from oxidative stress [13]

Park SM

This sets up a vicious loop: hyperglycemia oxidative stress low GSH worse insulin resistance more hyperglycemia