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This leads to a dysfunction in ATP-dependent ion transport processes, culminating in increased intracellular and mitochondrial calcium levels (calcium overload), cellular swelling, rupture, and cell death via various pathways including necrosis, apoptosis, and autophagy

We then investigated whether IRE1 controls the expression of GCL enzymes and identified that IRE1 suppresses GCLC expression at both the mRNA and protein levels (Fig

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73,74 Tumor suppressor BRCA1-associated protein 1 (BAP1) frequently mutated or deleted in sporadic human cancers, inactivation of BAP1 inhibited ferroptosis by releasing SLC7A11 inhibition, thus BAP1 mutated cancer cells were sensitive to SLC7A11 inhibitor erastin

Humanistic health management and cancer: associations of psychology, nutrition, and exercise with cancer progression and pathogenesis

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