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While NM loss is localised only to the SN and LC in PD, increases in brain tissue iron concentration in PD relative to controls are seen throughout the brain using QSM 60,61,62 , most commonly in the basal ganglia

Faure V, Dou L, Sabatier F, Cerini C, Sampol J, Berland Y, Brunet P, Dignat-George F (2006) Elevation of circulating endothelial microparticles in patients with chronic renal failure

In fact, growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline (Jin et al., 2015)