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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Mizushima N, Komatsu M

These may include decreased energy levels and chronic fatigue, reduced lean muscle mass and increased body fat accumulation, diminished exercise capacity and physical endurance, impaired sleep quality and disrupted circadian rhythms, decreased bone density and increased fracture risk, cognitive changes including reduced memory and concentration, and diminished overall sense of wellbeing

Ther Adv Hematol 29(11):2040620720955000 Sagi V, Mittal A, Tran H, Gupta K (2021) Pain in sickle cell disease: current and potential translational therapies

This result in turn implies the occurnace of the thiol-ene click reaction between TPE-DCV and the intracellular thiols-mainly GSH

Data availability The data that support the findings of this study are available from the corresponding author, upon reasonable request

Hashimotos thyroiditis is an autoimmune disorder where the immune system mistakenly attacks the thyroid gland, leading to chronic inflammation and damage