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As mechanistic insights into iron homeostasis, lipid peroxidation, and immunometabolic interactions continue to deepen, alongside progress in drug delivery, gene editing, and regenerative medicine, therapies targeting ferroptosis may represent a promising new paradigm in OA management, ultimately enhancing joint function and overall quality of life for affected individuals

Rutin, quercitin and other bioflavonoids are found in buckwheat and strengthen small blood vessels against bruising, hemorrhoids and varicose veins

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Age at baseline and sex were included as fixed effects in the LMMs and individual and study centre were included as random effects, with individual nested under the study centre