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consequently, extrahepatic manifestations related to this mutation (diarrhoea, fever) are scarce compared to those related to ATP8B1 [55]

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The first step of tryptophan catabolism via the kynurenine pathway is mediated by the enzymes tryptophan 2,3-dioxygenase (TDO), and indoleamine 2,3-dioxygenase (IDO) to produce kynurenine

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

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Many factors, including reactive oxygen species (ROS), are involved in AD pathogenesis by causing cellular damage and inflammation resulting in skin barrier dysfunction