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The researchers attributed this to enhanced cholinergic activity and synaptic plasticity

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Dialogues Clin Neurosci 8:383395

Abstract Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain

This is because B12 in this form has low bioavailability with absorption typically around ~1-2%

After centrifugation for 10 min at 20,000 g and 4 C, supernatants were subjected for HPLC analysis using a DIONEX UltiMate 3000 system with Corona Veo SD Charged-Aerosol-Detector (Thermo Scientific GmbH, Dreieich, Germany)