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Enzymes involved in lipid metabolism may also be the appropriate target to prevent the formation of brain metastases, because oncogenic lipid signaling can promote the metastasis of breast tumor cells to the brain by supporting cell survival, migration, and invasion (154)

Kumar A, Chamoto K, Chowdhury PS, et al

J Pineal Res 67(1):e12572 Khan A, Numan M, Khan AL, Lee IJ, Imran M, Asaf S, Al-Harrasi A (2020) Melatonin: awakening the defense mechanisms during plant oxidative stress

Axitinib reduced the destruction of tight junction proteins and reduced BBB permeability in mice, while increasing spatial awareness, exploration, associative memory, working memory, and lowering -amyloid levels (Yuan, et al