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10.1146/annurev.biochem.74.082803.133518 Annu

Tharp, Indiana University Bloomington, United States Updates Copyright 2024 Kim, Cho, Kim and Park

In another study, IGF-1 was shown to regulate glucose metabolism in cancer cells with the involvement of kallikrein-related peptidase 10 (KLK10) and the knockdown of KLK10 markedly inhibited glucose metabolism and PI3K/Akt/mTOR signaling activation, a process that could be reversed by IGF-1, suggesting that IGF-1 and KLK10 serve as potential targets for regulating metabolic remodeling in colon cancer (79)

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In particular, arachidonic acid (AA) and adrenic acid (AdA) are highly peroxidizable fatty acids that can be incorporated into membrane phospholipids and subsequently drive lipid peroxide propagation [35]

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