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Topical Glutathione If using glutathione-containing creams or serums (sometimes offered for localized hyperpigmentation or melasma), the timeline could be similar to other lightening topicals, expect at least 810 weeks of daily application to see improvement

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The presence of enzymes in the trans-sulfonation and remethylation pathways in human kidney tissue implies the potential involvement of renal metabolism in these processes [58]

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