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Unlike many cofactors that directly participate in redox reactions, zinc's biological role largely involves structural stabilization and catalytic activity, making it indispensable in processes such as transcription, signal transduction, immune function, and apoptosis [5] (Tables 1 and 2)

O'Daniel JC, Rosenthal DI , Garden AS, Barker JL, Ahamad A, Ang KK, Asper JA, Blanco AI, de Crevoisier R, Holsinger FC, Patel CB, Schwartz DL, Wang H, Dong L

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thus, clinical application awaits further verification of safety and efficacy, and they are not recommended for routine clinical use at present but are considered as exploratory research directions