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It is widely prescribed for the management of peripheral neuropathy, diabetic neuropathy, and megaloblastic anemia caused by Vitamin B12 deficiency

This usually involves: 1,000 mcg of B12 injected daily or every other day for 1-2 weeks Followed by weekly injections for a month 2

This derivative was already used in in vivo studies and serves as a first proof of concept for this receptor targeting approach

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Notably, the administration of non-competitive inhibitors of stomach ADH, such as Cimetidine, increases alcohol bioavailability when alcohol is ingested but has no effect when the same dose of alcohol is administered intravenously (87, 88)

Trial protocols describe rotating injection sites