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180 In preclinical models of breast cancer, some novel nanomedicines that target cuproptosis have demonstrated efficacy in inhibiting tumor growth and may hold potential for future clinical applications

Glutamine is first transported into the cell and then into the inner mitochondrial membrane via specific transporters before being converted into glutamate by mitochondrial glutaminase

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Tumor progression is profoundly influenced by cancer cells interactions with the TME, which ultimately determine whether the primary tumor is eradicated, metastasizes, or establishes dormant micrometastases