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Only female mice were used due to known sex differences in rodent salivary glands, with female glands more accurately emulating human salivary gland structure and function 29, 30

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For example, the mutant presenilin 1, one of the main causes of familial AD, was found to cause a dysfunction in lysosomal acidification, leading to elevated lysosomal pH values 125 , lysosomal proteolysis injury, and AD-like pathologic alterations 126

Xiao X, Li X, Shi F, Chen Y

Its systemic (all over)

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