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The proposed mechanisms behind BPC-157 center on four distinct biological processes, which are the formation of new blood vessels, the reorganization of the extracellular matrix, the proliferation of fibroblasts, and inflammatory regulation

The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

10.1038/nrurol.2014.194 11 BonizziG.PietteJ.SchoonbroodtS.GreimersR.HavardL.MervilleM

The advantage to starting earlier is that its easier to prevent the signs of aging, then it is to reverse them

doi: 10.1136/lupus-2023-000987 118 ReddyVJayneDCloseDIsenbergD