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Sulforaphane-rich cruciferous vegetables have been shown to modulate CYP3A4 activity and enhance aflatoxin B1 detoxification, which is particularly relevant for individuals with reduced-function CYP3A4 or GST/UGT variants.[ref][ref] On the conjugation side, phase II enzymes determine how quickly reactive mycotoxin intermediates are neutralized and excreted from the body

Conversely, high levels of matrix ROS can activate a supraphysiologic uncoupling protein 2 (UCP2)-dependent increase in proton leak, impairing GSIS (Mailloux et al., 2012)

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