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3,17 Like the pro-IL-1 gene, the NLRP3 gene is a direct target of NF-B and contains NF-B-binding sites in its promoter region

From the clinical trials, compared to the other drugs piribedil was found to be more effective and safe for the treatment of RLS hence suggested as the first line treatment

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doi: 10.25259/IJMR_1065_2024 15 Szymulewska-KonopkoKResze-GieaynJMaeczekM