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They operate these mechanisms, inhibition of cell death, and protection of cells against damage

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Closer inspection of the MPP lid region reveal two other regions which re-arrange upon PINK1 binding namely, portions of the PRQ-helix, which lies next to the RLY helix, and the short HIQT-helix, which lies next to the PRQ-helix (Fig 4B)

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These alterations contribute substantially to the blunted and delayed perfusion responses observed in aging, with implications for both basic research and clinical assessment of cerebrovascular health (Zimmerman et al., 2021