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In this process, membrane receptors signal calcium channels, which cause cannabinoids to bind to receptors, generating a cascade of reactions, such as inhibition of adenylate cyclase, decrease in cyclic AMP levels, and opening of potassium channels, which will decrease the transmission of signals that will generate an inhibition of the release of neurotransmitters, such as GABA and glutamate 51

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Abbreviations 6-AN: 6-aminonicotinamide AOA: amino-oxyacetate G6PD: glucose-6-phosphate dehydrogenase GLS2: glutaminase 2 GSH: glutathione LA: lactic acidosis NADPH: nicotinamide adenine dinucleotide phosphate PCR: polymerase chain reaction PPP: pentose phosphate pathway ROS: reactive oxygen species TCA: tricarboxylic acid cycle TKT1: transketolase 1

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