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Oxygen supply to kidney tissue regions is determined by blood flow

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A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes

Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections

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The fast reactivity of PAT was confirmed in vivo and in vitro where no PAT could be detected in human serum after ingestion of PAT containing apple juice and a reduction of PAT levels by 94% within two minutes of incubation of PAT in a human blood sample (Rychlik 2003)