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doi: 10.1186/s12882-022-02890-9 100 MafraD.BorgesN

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This produces an incompletely O 2 reduction (Hamanaka et al., 2013)

M1 macrophages play a key role in the initial stages of the inflammatory response by releasing considerable amounts of inflammatory agents such as tumor necrosis factor (TNF-), IL-6 and IL-12, which contribute to aggravating inflammation