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This shift not only allows for rapid production of energy but also for maintenance of NADH/NAD + redox ratio, which is required for metabolic processes, such as aerobic glycolysis, the TCA cycle, OXPHOS, FAO, serine biosynthesis and antioxidant defense

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In previous reports, single modulation of G pathway and F pathway for GSH production could achieve GSH contents of 1.51.7 % [19, 22] (Table 1)

Notably, even in the absence of FOXO4 FH , we observed an -helical population of TAD1, which slightly increased in presence of FOXO4 FH