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For chronic administration, the bone study by Svensson et al., 2000 used subcutaneous 0.5 mg/kg per day over twelve weeks

However, in some chronic diseases and with some medications taken for long periods, the swelling becomes chronic and the skin becomes more rigid, reddish, and sometimes mildly discolored or mottled and will not return to normal after a few hours of elevation

10.1007/s10517-016-3237-1 75 KorshunovS.ImlayJ

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