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In 1996, a polymorphism in the 5-LO gene promoter was identified, consisting of a variable number of tandem repeats of GC-rich motifs necessary for the activity of the Sp1 and Egr1 transcription factors

[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Yuan D., Xu Y., Kong B., Cao C., Zhang F., Xia X., Zhang H., Liu Q., Zhao J

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The vascular endothelial growth factor (VEGF) is one of the most studied pro-angiogenic factors, and its overexpression is frequently associated with poor prognosis in various cancers, including gastrointestinal tumors ( Recent advancements in the understanding of tumor angiogenesis have led to the development of innovative strategies that not only inhibit vessel formation but also aim to normalize the abnormal tumor vasculature

Five other patients could not proceed with further treatments due to financial difficulties

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