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Nat Struct Mol Biol (2011) 18(9):9716.10.1038/nsmb.2099 83 BandaranayakeRMUngureanuDShanYShawDESilvennoinenOHubbardSR

61 Moreover, significant downregulation of the brain metastatic lncRNA suppressor X-inactive-specific transcript (XIST) in metastatic tumour cells leads to augmented secretion by these cells of exosomal miRNA-503, which triggers M2 polarisation and the accumulation in microglia of immune-suppressive cytokines, subsequently inhibiting T-cell proliferation

Simultaneous inhibition of CXCR1/2, TGF-beta, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

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Data are presented as fold change relative to the nuclear gene for CLN3 patient and control astrocytes

10.1016/s0959-437x(00)00193-3 Curr Opin Genet Dev