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As mentioned in previous sections, folate is required for the synthesis of SAM, the primary methyl donor in cellular methylation reactions

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Interestingly, this effect was at least partially independent of PPAR-alpha, as it was not abolished by a PPAR-alpha antagonist (GW6471) (Fig

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Proc Natl Acad Sci USA 92 : 62646268 Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH Jr, Scott RW, Snider WD 1996 Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury