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XT and JW searched the literature and drafted the manuscript

Abstract Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment

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Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene

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CSCs exhibit alterations in iron metabolism, including enhanced iron uptake, intracellular iron accumulation, and dysregulated antioxidant defense systems, rendering them particularly vulnerable to ferroptosis induction