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Further, many reported small-molecule inhibitors target several metabolic enzymes with similar structures, for example, EGCG targets both NADPH-dependent FASN and NADP + -dependent GDH

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The first and rate-limiting step is catalyzed by an enzyme called glutamate-cysteine ligase (GCL), which links glutamate and cysteine together

Im zweiten Schritt der Synthesekette wird unter ATP-Verbrauch Alanin mithilfe des Enzyms Homoglutathionsynthetase an das terminale Kohlenstoffatom addiert

[DOI] [PubMed] [Google Scholar] [76].Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, et al

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