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Furthermore, in the RSV, HMPV, and EBOV polymerase structures, both loops either withdraw from the central cavity or are missing, indicating an elongation conformation 8,32,33,34 (Fig

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This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome