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doi: 10.1038/s41585-020-0346-4 48 WangSWangJChenZLuoJGuoWSunLet al

In summary, development defects in the CNS in GDH-HI patients could be caused by multiple factors, including chronic hyperammonemia, and hyperinsulinemia, the more detailed mechanisms need to be further studied

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Patients prioritising cost-per-dose and maximum shelf life should use lyophilised refills and reconstitute in smaller batches

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