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The CAR inhibitor CINPA1 worsens sepsis survival, associated with disrupted hepatic metabolism, systemic inflammation and organ damage To further investigate the functional consequences of hepatic CAR loss-of-function in sepsis, mice were treated for 4 days with the CAR inhibitor CINPA1 or with vehicle ( Figure 6A )

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A later double-blind study in chronic insomnia found modest differences vs placebo on some measures, but the authors also pointed out that the effects were weak