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Although both ROS and RNS are essential for many cellular functions, they require strict regulation by antioxidant systems

Zhao Y, Li D, Wang S, Zhao W, Zhang Z, Zhang H et al (2024) Clinical formulation Zhigan oral liquid intervenes in alcoholic liver injury by regulating the intestinal flora and PI3KAKTNF-B pathway

Additionally, multiple studies have indicated that the inhibition of the Nrf2/HO-1 pathway is associated with ferroptosis in conditions such as diabetic nephropathy 66 , transplanted islets 67 , acute lung injury 68 , and blood-brain barrier dysfunction 69

Certain B vitamins, particularly vitamin B6 and B12, are excreted through the kidneys, and accumulation may occur in severe renal dysfunction

Manipulation of the intestinal microbiome in newborn infants

At the same time, AOD-9604 has been investigated for its capacity to control inflammation